glycerol-3-phosphate dehydrogenase (NAD)
function
biosynthesis of phospholipids
product
glycerol-3-phosphate dehydrogenase (NAD)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation]Gene
Coordinates
2,389,151 2,390,188
Phenotypes of a mutant
essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]poor growth [pubmed|28189581]poorly transformable [pubmed|28189581]The protein
Catalyzed reaction/ biological activity
sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H (according to Swiss-Prot)Protein family
NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)Structure
[PDB|3K96] (from ''Coxiella burnetii RSA 493'', 37% identity, 59% similarity)[SW|Localization]
cytoplasm [Pubmed|15743965]Expression and Regulation
Operons
genes
[gene|B2270316642C66BC2DA86EBDCD1BF6A33CC6A1DC|yphC]-[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]
description
[pubmed|22383849]
view in new tabgenes
[gene|5DA8B27AC6A0E0B4115512BD948C31964D387A8E|yphA]-[gene|448375DF74EB0482A6CD1ACFE04D117C1319E2B2|seaA]-[gene|910109496E4A41EC892996DEEB81971FCBD9CB05|ypzH]-[gene|B2270316642C66BC2DA86EBDCD1BF6A33CC6A1DC|yphC]-[gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]
description
[pubmed|22383849]
view in new tabBiological materials
Mutant
BKE22830 ([gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATGTTTGATTCACACC, downstream forward: _UP4_TAAAAGTGTCAATCAAATGGBKK22830 ([gene|8440C1DBE485BB9EF2904FAA5D709A574C3819A4|gpsA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22830 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATGTTTGATTCACACC, downstream forward: _UP4_TAAAAGTGTCAATCAAATGGReferences
7592341,15743965,28189581